Figure 1.

Schematic representation of the BCOR (top) and BCORL1 (bottom) transcriptional corepressors with their respective domains and the location and type of mutations occurring in AML patients. The numbers above the arrows indicate the presence, in more than one case, of the same type of mutation occurring at the same exonic location or involving the splicing of the same intron. BCORL1 mutations also include five mutations that were found in four AML cell lines and in the Jurkat T-lymphoblastic leukemia cell line. The specific type (i.e. frameshift, nonsense, missense or splice-site) of BCORL1 mutations was inferred from Li et al.⁹