Figure 1.

(A) Schematic representation of the 750 Kb region from the telomere of the short arm of chromosome 16 analyzed by Multiplex Ligation-dependent Probe Amplification (MLPA). The position of the 35 MLPA-probe pairs along the region is indicated by green, red and blue arrows, referring to HEX, ROX and FAM labeling, respectively. The duplicated region is indicated as arched red bars and spans at least 175 Kb. (B) Real-time polymerase chain reaction experiments: the graphs show the mean and standard deviation of three different experiments. The expression of α and β globin genes is compared to β-actin and β-2 microglobulin house-keeping genes.