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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Nov 4;22(1):537–542. doi: 10.1016/j.bmcl.2011.10.096

Scheme 1.

Scheme 1

Synthesis of 8a–8s

Reagents and conditions (i) 3 (1 equiv.), 4 (4 equiv.), K2CO3 (2 equiv.), DMSO, 40°C, 4h, 65%; (ii) 5 (1 equiv.), 6 or 7 (2 equiv.), K2CO3 (2 equiv.), DMSO, 40°C, 4h, 50–98%.