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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Nov 4;22(1):537–542. doi: 10.1016/j.bmcl.2011.10.096

Scheme 2.

Scheme 2

Synthesis of 13a, 13b, 13c

Reagents and conditions: (i) 6 (1 equiv.), 1,3-dibromopropane (4 equiv.), K2CO3 (2 equiv.), DMSO, 40°C, 4h, 65%; (ii) 10 (1 equiv.), PBr3 (0.33 equiv.), CH2CI2, 0°C to rt, 3h, 85%; (iii) 9 or 11 or 12 (1 equiv.), 3 (1 equiv.), K2CO3 (2 equiv.), 40°C, 4h, 75–90%.