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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Nov 4;22(1):537–542. doi: 10.1016/j.bmcl.2011.10.096

Table 3.

S1P4-R agonist activity of 22a–22aa

cpd Ar2 EC50 (nM)α
22a I graphic file with name nihms336544t7.jpg 2980
22b II graphic file with name nihms336544t8.jpg NA
22c III graphic file with name nihms336544t9.jpg 1300 (40%)β
22d IV graphic file with name nihms336544t10.jpg 304
22e V graphic file with name nihms336544t11.jpg 4800
22f graphic file with name nihms336544t12.jpg NA
22g graphic file with name nihms336544t13.jpg NA
22h VI graphic file with name nihms336544t14.jpg NA
22i VII graphic file with name nihms336544t15.jpg NA
22j VIII graphic file with name nihms336544t16.jpg 2600 (65%)β
22k IX graphic file with name nihms336544t17.jpg 7300
221 X graphic file with name nihms336544t18.jpg 52
22m XI graphic file with name nihms336544t19.jpg 1300
22n XII graphic file with name nihms336544t20.jpg 46
22o XIII graphic file with name nihms336544t21.jpg 208
22p XIV graphic file with name nihms336544t22.jpg 54
22q XV graphic file with name nihms336544t23.jpg NA
22r XVI graphic file with name nihms336544t24.jpg 6000 (70%)β
22s XVII graphic file with name nihms336544t25.jpg NA
22t graphic file with name nihms336544t26.jpg 287
22u graphic file with name nihms336544t27.jpg 2100
22v XVIII graphic file with name nihms336544t28.jpg 1500
22w graphic file with name nihms336544t29.jpg 1800
22x graphic file with name nihms336544t30.jpg NA
22y graphic file with name nihms336544t31.jpg 658
22z graphic file with name nihms336544t32.jpg NA
22aa graphic file with name nihms336544t33.jpg 45
α

Data are reported as mean of n = 3 determinations.

β

Percentage of response at given concentration. NA = not active at concentrations up to 25 μM.