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S1P1–3,5-Rs selectivity counter screen
| cpd | EC50 nMα | ||||
|---|---|---|---|---|---|
| S1P4-R | S1P1-R | S1P2-R | S1P3-R | S1P5-R | |
| 2 | 162 | NA | NA | NA | NA |
| 8g | 232 | NA | NA | NA | NA |
| 8h | 220 | NA | NA | NA | NA |
| 8r | 601 | NA | NA | NA | NA |
| 8s | 570 | NA | NA | NA | NA |
| 22d | 304 | NA | NA | NA | NA |
| 22l | 52 | NA | NA | NA | NA |
| 22n | 46 | NA | NA | NA | NA |
| 22p | 54 | NA | NA | NA | NA |
| 22t | 287 | NA | NA | NA | NA |
| 22aa | 45 | NA | NA | NA | NA |
Data are reported as mean of n = 3 determinations. NA = not active at concentrations up to 25 μM.
