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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Drug Discov Today. 2011 Sep 18;17(3-4):124–134. doi: 10.1016/j.drudis.2011.09.011

Figure 2.

Figure 2

Matrix metalloproteinases (MMPs) and their substrates in myocardium. Collagenases (MMP-1, -8 and -13) have high substrate specificity for fibrillar collagens (e.g. collagen I, II and III) and extracellular matrix (ECM) proteins (proteoglycans, perlican, aggrecan, versican, etc.). Stromelysins (MMP-3 and -7) can digest ECM proteins and basement membrane proteins (e.g. collagen IV and fibronectin). Additionally, MMP-7 also degrades fibrillar collagens. The substrates for gelatinases (MMP-2 and -9) include gelatins, basement membrane proteins and ECM proteins. Membrane-type (MT-) MMPs breakdown basement membrane components, fibrillar collagens and ECM proteins.