Figure 5. Manipulation of vesicular zinc fails to influence mossy fibre-evoked Ca²⁺ signals in CA3 pyramidal cells.

AbandBb, plots showing integral of Ca²⁺ release from internal stores, evoked by repetitive mossy fibre stimulation (20 times, 100 Hz) in individual pyramidal cells from wild-type (n = 8, A) and ZnT3 KO (n = 9, B) mice. Mossy fibre origin of stimulation was confirmed with DCG-4 application.AcandBc, summary bar graphs showing average integral (Ac) and peak amplitudes (Bc) of Ca²⁺ signals recorded in wild-type (n = 18) and ZnT3 KO (n = 10) animals. Neither parameter was significantly changed in the absence of vesicular zinc.