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. 2011 Oct 17;589(Pt 23):5801–5818. doi: 10.1113/jphysiol.2011.214320

Figure 11. Frequency-dependent depression of EPSP amplitude in cardiac vagal ganglion principal cells.

Figure 11

A, recording of a principal cell with spontaneous EPSPs showing the increased frequency of events in the postinspiratory phase (membrane potential hyperpolarised by current injection to prevent action potential discharge). It was also notable that as the inter-EPSP interval shortened so the amplitude of each EPSP appeared to be attenuated. (Note the monopolar phrenic nerve recording also includes the ECG signal.)B, a log-log plot of EPSP amplitude against time since the previous EPSP revealed a striking correlation, indicating that synaptic transmission at this site shows frequency-dependent depression.