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. 2011 Oct 17;589(Pt 23):5879–5895. doi: 10.1113/jphysiol.2011.220533

Figure 8. The FHM1 mutation does not significantly affect depolarization-evoked CGRP release from the dura, but it increases depolarization-evoked CGRP release from the trigeminal ganglion.

Figure 8

A, left: CGRP released from the dura in hemisected skulls from WT (n = 9) and R192Q KI mice (n = 12) in control solution, after stimulation with 35 mm K+ and after wash. Right: relative stimulation of CGRP release, obtained by dividing the CGRP released in 35 mm K+ by the average of the CGRP released in control and after wash.B, left: CGRP released from intact isolated trigeminal ganglia from WT (n = 16) and R192Q KI mice (n = 10) in control solution, after stimulation with 35 mm K+ and after wash. Right: relative stimulation of CGRP release, obtained as inA.