TABLE 2.
In vitro cytotoxicity of the model peptide analogs
| Peptide | Cytotoxic activity (EC50)a,b |
|||
|---|---|---|---|---|
| MethA | MT-1 | HT-29 | MRC-5 | |
| μm | ||||
| Z1 | >211 | 186 | >211 | NDc |
| Z2 | >211 | 173 | >211 | ND |
| Z3 | >211 | 128 | >211 | ND |
| Z4 | 155 | 68 | 173 | 78 |
| Z5 | 42 | 28 | 67 | 27 |
| Z6 | 17 | 16 | 31 | 23 |
| Z7 | 15 | 15 | 21 | 20 |
| Z8 | 19 | 14 | 23 | 17 |
| Z9 | 9 | 16 | 13 | 14 |
| Z10 | >211 | >211 | >211 | ND |
a The maximum concentration of the peptide used was 211 μm, whereas the minimum concentration tested was 4.2 μm. The results are an average value of three independent experiments performed in duplicate.
b EC50 corresponds to the peptide concentration where 50% of the cells are killed.
c ND, not determined.