TABLE 1.
Overview of 20 genes whose expression was most strongly induced by IL-27 in DLD-1 cells after 6 h of stimulation (p < 0.05 versus unstimulated and adjusted for multiple testing)
| Gene ID | Gene symbol | Description | -Fold increase |
|---|---|---|---|
| NM_003955 | SOCS3 | Suppressor of cytokine signaling 3 | 17.34 |
| NM_002164 | IDO1 | Indoleamine-pyrrole 2,3-dioxygenase | 13.83 |
| NM_018664 | BATF3 | Basic leucine zipper transcription factor, ATF-like 3 | 11.88 |
| NM_007329 | DMBT1 | Deleted in malignant brain tumors 1 | 8.13 |
| NM_018027 | FRMD4A | FERM domain containing 4A | 7.74 |
| NM_000014 | A2M | α2-Macroglobulin | 7.58 |
| NM_182920 | ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 7.24 |
| X94553 | FOXE1 | HFKH4 mRNA for forkhead-like protein | 6.66 |
| NM_144586 | LYPD1 | LY6/PLAUR domain containing 1 | 6.56 |
| NM_000246 | CIITA | Class II, major histocompatibility complex, transactivator | 6.52 |
| NM_152486 | SAMD11 | Sterile α motif domain containing 11 | 6.06 |
| THC2559929 | THC2559929 | SNC73 protein, partial (54%) | 5.84 |
| NM_002089 | CXCL2 | Chemokine (CXC motif) ligand 2 | 5.82 |
| NM_006161 | NEUROG1 | Neurogenin 1 | 5.77 |
| NM_006169 | NNMT | Nicotinamide N-methyltransferase | 5.74 |
| NM_138700 | TRIM40 | Tripartite motif-containing 40 | 5.70 |
| NM_006851 | GLIPR1 | GLI pathogenesis-related 1 (glioma) | 5.56 |
| NM_013271 | PCSK1N | Proprotein convertase subtilisin/kexin type 1 inhibitor | 5.27 |
| NM_006705 | GADD45G | Growth arrest and DNA damage-inducible, γ | 5.24 |
| NM_014069 | PSORS1C2 | Psoriasis susceptibility 1 candidate 2 | 4.80 |