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Comparison of ΔTK2/l-18F-FMAU and sr39tk/18F-FHBG PET reporter gene systems. A, shown are l-18F-FMAU microPET/CT scans of mice bearing L1210 tumors engineered to express various TK2-based PRGs. B, shown are 18F-FHBG microPET/CT scans of mice bearing L1210 tumors engineered to express sr39tk. C, shown is quantification of probe uptake in L1210 tumors from A and B. %ID/g, % injected dose/g.
