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Schematic illustrating the respective roles of GST P1-1 and MRP1 in NO storage and transport. NO can diffuse through the membrane or may be actively transported into cells by protein disulfide isomerase (PDI) (37). Due to the ability of NO to act as a ligand, it can bind iron transported into cells and released from transferrin. GSH completes the NO-Fe complex to form a DNIC. DNICs can be bound by GST P1-1 or effluxed out of cells via MRP1.
