Fig. 1.

Summary of modification sites identified by LC–MS/MS on immunopurified PHF-tau. The sequence shown is that of human 2N4R tau (NCBI accession number NP_005901). Bold sequence coverage; Red PHF6 and PHF6* motifs; dashed lines segments encoded by alternatively spliced exons 2, 3, and 10; underline repeat region (as defined in [23]); P Phosphorylated sites, U Ubiquitylated sites, me1 monomethylated sites identified from MS analysis reported herein and in [13]