. 2011 Jul 8;68(1):29–37. doi: 10.1007/s00228-011-1094-4

Table 3.

The major pharmacokinetic parameters of aripiprazole and dehydroaripiprazole in CYP2D6 EMs and IMs with and without of fluvoxamine (FLV)

CYP2D6 genotype	Aripiprazole						Dehydroaripiprazole
CYP2D6 genotype	EM (n = 6)			IM (n = 7)			EM (n = 6)			IM (n = 7)
Dose	APZ alone	APZ + FLV	Ratio/difference	APZ alone	APZ + FLV	Ratio/difference	APZ alone	APZ + FLV	Ratio/difference	APZ alone	APZ + FLV	Ratio/difference
C_max (ng/mL)	14.7 ± 2.9	20.5 ± 4.0	1.39^a	15.3 ± 3.4	19.3 ± 3.9	1.27^a	1.3 ± 0.3	1.6 ± 0.2	1.23^a	1.2 ± 0.3	1.2 ± 0.3	0.95^a
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t_max (h)	2.7 ± 1.4	2.0 ± 1.5	−0.67^b	3.0 ± 1.8	3.0 ± 1.8	0.00^b	60.0 ± 13.1	72.0 ± 0.0	12.00^b	120.0 ± 41.6	157.7 ± 36.3	37.71^b
t_1/2,z (h)	76.5 ± 14.7	109.5 ± 14.3	1.44^a	105.3 ± 6.8	157.2 ± 19.0	1.49^a	115.0 ± 39.6	227.8 ± 63.2	2.00^a	141.7, 153.0^c	-	-
CL/F (L/h)^a	3.30 ± 0.59	2.03 ± 0.46	0.61^a	2.10 ± 0.69	1.26 ± 0.35	0.60^a

Values are mean ± standard deviation, dashes indicate values that could not be calculated

EM Extensive metabolizer, IM intermediate metabolizer

^aRatio (period II/period I)

^bDifference (period II − period I)

^c n = 2 (number of subjects with available data for pharmacokinetic analysis)