Table 5.
Top genome-wide significant genes associated with femoral neck BMD in 6,636 adults
| Chr | Gene | Start position | End position | Southern Chinese (n = 778) | European (n = 5,858) | Meta p | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number of SNPs | Test statistic | Gene-based p | Number of SNPs | Test statistic | Gene-based p | |||||
| Significant gene | ||||||||||
| 11 | LRP4 | 46834993 | 46896652 | 10 | 43.6 | 0.016 | 12.000 | 126.5 | 4.0E−06 | 1.2E−06 |
| 11 | CKAP5 | 46721659 | 46824419 | 13 | 36.9 | 0.065 | 12.000 | 144.9 | 1.1E−05 | 5.2E−06 |
| Suggestive gene | ||||||||||
| 6 | C6orf97 | 151856919 | 151984021 | 69 | 23.9 | 0.978 | 41.000 | 270.1 | 2.0E−06 | 8.4E−06 |
| 11 | F2 | 46697318 | 46717632 | 9 | 24.8 | 0.068 | 7.000 | 80.7 | 3.4E−05 | 1.7E−05 |
| 9 | FOXE1 | 99655357 | 99658818 | 9 | 38.0 | 0.015 | 9.000 | 84.7 | 6.5E−05 | 2.2E−05 |
| 1 | LCE2A | 150937463 | 150938542 | 11 | 44.4 | 0.010 | 6.000 | 70.9 | 1.0E−04 | 3.2E−05 |
| 1 | KPRP | 150997129 | 151001153 | 16 | 18.4 | 0.329 | 7.000 | 85.3 | 3.6E−05 | 3.3E−05 |
| 1 | LCE4A | 150948146 | 150948534 | 12 | 37.1 | 0.023 | 6.000 | 79.5 | 8.9E−05 | 3.5E−05 |
| 20 | ADRA1D | 4149277 | 4177659 | 34 | 29.8 | 0.537 | 23.000 | 108.7 | 2.9E−05 | 3.6E−05 |
| 1 | LCE2B | 150925222 | 150926500 | 13 | 57.9 | 0.008 | 8.000 | 71.0 | 1.2E−04 | 3.7E−05 |
| 1 | LCE2C | 150914394 | 150915673 | 14 | 63.8 | 0.008 | 8.000 | 71.0 | 1.6E−04 | 5.0E−05 |
| 11 | C11orf49 | 46914826 | 47142507 | 23 | 121.2 | 0.005 | 20.000 | 140.1 | 1.8E−04 | 5.2E−05 |
| 11 | ZNF408 | 46678943 | 46684037 | 10 | 41.8 | 0.013 | 9.000 | 69.9 | 2.2E−04 | 7.9E−05 |
| 11 | ARHGAP1 | 46655207 | 46678696 | 9 | 37.7 | 0.012 | 8.000 | 57.0 | 3.1E−04 | 1.1E−04 |