Table 4.

Ethnic distribution of select K8 variants in acute and chronic liver disease patients

K8 Variant	Keratin Domain	AA (69)	Asian (92)	Caucasian (868)	Hispanic (91)
Y54H	Head	7.2a,b	0a	0.1b	1
G62C	Head	2.9	0	1.5	0
A333A	Rod	11.6c	0	0c	4.2
R341H	Rod	0d	1e	4.8f	14.3d,e,f
G434S	Tail	18.8g,h,i	0g	0h	1i
IVS7+8C>T†	Intronic	11.6k	0	0k	0

AA, African-American. Summarized are the percent of K8 variants in the indicated ethnic groups reported collectively in the study herein and in two prior independent chronic liver disease patient groups.^9,10 For each ethnic category the number in parenthesis represents the total patients examined [for some variants, one or two of the studies did not include the listed ethnic background; see Supplemental Table 4 for details regarding the specific number of patients for each category)

^†Not all patients were analyzed for the presence of the variant.

^ap=0.03;

^bp<0.001;

^cp<0.001;

^dp=0.003;

^ep=0.002;

^fp=0.0006;

^gp<0.001;

^hp<0.001;

ⁱp=0.0003;

^kp<0.001