Table 1.

Subsets with LOD > 2.0 or nominally significant increases in LOD scores (P<0.05) associated with lung cancer related covariates, as identified by OSA. “Cut points ” denote the cut points for the covariate in the selected subsets with maximum LOD. P-values in bold font were significant for a change in LOD score when modeling the covariate after imposing a Bonferronni correction

Chromosome and nearest marker	cM	LOD score	Change from baseline	P	One-LOD interval	Number of Families in the Subset	Covariate	Order	Cut points
5q31-q33 D5S816	139	2.45	2.85	0.004	132.7-153.5	6	Range of age at onset	Descending	≥40 years
6p21 D6S1017	63	3.35	2.39	0.118	52.8-69.0	12	Minimum age at onset	Ascending	≤39 years
6q23-25 D6S2436	158	3.66	2.70	0.0476	150.5-164.0	51	Number of affected individuals	Descending	≥5
6q23-25 D6S1035	168.2	4.19	3.23	0.0216	160-177.2	53	Proportion of smokers	Ascending	≤0.567
12q24.2 D12S2070	123.4	2.79	2.95	0.002	110.6-143.5	30	Maximum age at onset	Descending	≥78 years
14q11.2 D14S306	44	2.26	1.87	0.0358	14.8-51.2	14	Maximum pack-years	Descending	≥141 pack-years
16q24 D16S539	125	2.33	2.27	0.0008	119.4-140.0	44	Range of age at onset	Ascending	≤20 years
20p12 D20S604	34.8	2.20	2.37	0.160	21.1-39.9	49	Average age at onset	Descending	≥61.7 years