Table 2.

Significant increases in LOD score for lung cancer associated with other cancer risk, as identified by OSA. “Cut point “ denotes the cutoff value for the covariate in the selected subsets with maximum LOD. “*” represents the unit of incidence rate that is measured in” per 100 person-years”. None of increases in LOD score were significant after correction for testing multiple covariates on the same chromosome (P≤0.05/54=0.0009).

Chromosome and peak marker	CM	LOD score	Change from baseline	P-value	1-LOD interval	Number of families in the subset	Covariate	Order	Cut point
1q23 D1S1677	176	2.24	2.80	0.0287	168.9-189.6	18	Breast cancer incidence rate	Descending	≥0.158*
2p11.2 D2S1790	103	1.78	1.93	0.0389	99.4-112.9	13	Bladder cancer incidence rate	Descending	≥0.035*
6q23-25 D6S2436	159	4.06	3.10	0.0284	154.1-164	61	Digestive cancer incidence rate	Ascending	≤0.051*
13p12 D13S217	19.7	1.13	1.59	0.0417	11.4-42.5	8	Relative risk for leukemia	Descending	≥2.48
	19.7	1.13	1.59	0.0352	11.4-42.5	8	Leukemia incidence rate	Descending	≥0.017*
17p11.2 D17S799	35.9	1.34	1.40	0.0375	25.6-45.6	12	Relative risk for breast cancer	Descending	≥2.57
	37.2	1.34	1.39	0.0412	24.8-45.6	11	Breast cancer incidence rate	Descending	≥0.186 *