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Rigidity of the two LRP6-ECD structural blocks and hinge between these two blocks. (a) Superposition of two LRP6-E1E2 copies in the asymmetric unit of the LRP6-E1E2 crystal lattice. (b) Superposition of LRP6-E3E4 and LRP6-E1E2. LRP6-E3E4 and E1E2 are shown in green and cyan, respectively. (c) EM analysis of human LRP6-E1E4. (d) A model for the two structural blocks of the LRP6 extracellular domain and the hinge between these two blocks.
