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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Oct 9;18(11):1204–1210. doi: 10.1038/nsmb.2139

Figure 4.

Figure 4

Crystal structure of the LRP6-E3E4/DKK1c complex. (a) An overall view of the complex in two orientations roughly related by a horizontal 90° rotation. Only the interface A is shown here (see text). DKK1c is in magenta. (b) Stereo view of a representative portion of the Fo-Fc electron density map (contoured at 2.0 σ), showing the DKK1c loop 222–231 region. The map was calculated using phases from LRP6-E3E4 only. (c) Comparison of DKK1c and DKK2c structures. Crystal structure of DKK1 in the LRP6-E3E4/DKK1 complex (in light blue) and the NMR structure of DKK2c (in cyan) are superimposed.