Table 1.

Data collection and refinement statistics

	Human LRP6-E1E2	Human LRP6-E3E4	Human LRP6- E3E4/Dkk1c
Data collection
Space group	P21	P212121	P212121
Cell dimensions
a, b, c (Å)	70.54, 144.51, 70.76	68.6, 83.75, 166.62	92.97, 104.76, 158.8
α, β, γ (°)	90, 96.0, 90	90, 90, 90	90, 90, 90
Resolution (Å)	30–2.8(2.95–2.8)	30–2.8(2.95–2.8)	30–3.1(3.21–3.1)
Rsym	9.1(33.5)	9.7(41.3)	11.4(62)
I/σI	7(2.3)	4.8(1.8)	11(1.7)
Completeness (%)	100(100)	99.9(100)	98.4(92.8)
Redundancy	3.9(4.0)	6.8(7.1)	3.3(2.9)
Refinement
Resolution (Å)	30–2.8	30–2.8	30–3.1
No. reflections	32951	23097	27740
Rwork/Rfree	24.4/30.2	25.2/27.9	24.3/29.2
No. atoms
Protein	9336	4833	10178
Ligand/ion	70	70	–
B-factors
Protein	70.04	91.9	87.1
Ligand/ion	137.2	138.4	–
R.m.s. deviations
Bond lengths (Å)	0.0085	0.006	0.007
Bond angles (°)	1.21	1.1	1.08

One crystal was used for each dataset. Values in parentheses are for highest-resolution shell.