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. Author manuscript; available in PMC: 2012 Dec 15.
Published in final edited form as: Cancer Res. 2011 Oct 11;71(24):7376–7386. doi: 10.1158/0008-5472.CAN-11-1154

Figure 4. Cytochrome-driven Xenobiotic Metabolism is altered in Bladder Cancer.

Figure 4

A. Network view of the molecular concept analysis for the metabolomic profiles of our “BCa associated metabolic signature” (black node). Each node represents a molecular concept or a set of biologically related genes. The node size is proportional to the number of genes in the concept. Each edge represents a statistically significant enrichment (FDR q-value < 0.10). Enriched concepts describing cytochrome P450-driven xenobiotic metabolism and methylation in BCa indicated by yellow and blue edges respectively. B. Box plots for real time PCR data showing relative transcript levels for enzymes in phase I/II metabolic pathway in matched BCa (red) and adjacent benign tissues (green). C. Immunoblot of CYP1A1 and CYP1B1 in bladder tumors compared to their matched benign adjacent tissues.