Table 2 . Top 10 hits for transcription factor enrichment analysis of random forest outputs (% of total) for strain discriminatory genes in the total gene list and in the metabolism-specific subset.

All genes	%	Metabolic genes	%
Ste12	39	Ste12p	45
Sfp1p	36	Sok2p	29
Yap1p	33	Rap1p	26
Rap1p	26	Yap6p	24
Aft1p	26	Cin5p	24
Sok2p	25	Phd1p	19
Msn2p	24	Skn7p	17
Met4p	24	Tec1p	17
Msn4p	18	Nrg1p	17
Rpn4p	18	Ino4p	17