Table 6.4.
Drug Inhibitors of the ASBT
| Compound | Ki | Description | Compound | Ki | Description |
|---|---|---|---|---|---|
| Nifedipine | 4 | Dihydropyridine CCB1; antihypertensive | Pioglitazone | 55 | Thiazolidinedione (TZD); hypoglycemic |
| Nisoldipine | 5 | Dihydropyridine CCB; antihypertensive | Propafenone | 62 | Sodium channel blocker; Class 1c anti-arrhythmic |
| Nimodipine | 6 | Dihydropyridine CCB; antihypertensive | Indomethacin | 62 | Non-steroidal anti-inflammatory |
| Simvastatin | 10 | Statin; hypolipidemic | Mevastatin | 65 | Statin; hypolipidemic |
| Latanoprost | 11 | Prostaglandin analog; glaucoma | Manidipine | 73 | Dihydropyridine CCB; antihypertensive |
| Fluvastatin | 12 | Statin; hypolipidemic | Pentamidine | 76 | Antimicrobial |
| Niguldipine | 16 | Dihydropyridine CCB; antihypertensive | Azelnidipine | 86 | Dihydropyridine CCB; antihypertensive |
| Mesoridazine | 18 | Piperidine neuroleptic; schizophrenia | Bendroflumethiazide | 93 | Thiazide diuretic; antihypertensive |
| Isradipine | 19 | Dihydropyridine CCB; antihypertensive | Doxorubicin | 101 | Anthracycline antibiotic; antineoplastic |
| Lovastatin | 22 | Statin; hypolipidemic | Spironolactone | 110 | Aldosterone antagonist; diuretic |
| Nemadipine A | 23 | Dihydropyridine CCB | Atropine | 170 | Tropane alkaloid; muscarine acetylcholine receptor antagonist |
| Cyclosporin A | 24 | Cyclic peptide; immunosuppressant | Ketoprofen | 178 | Non-steroidal anti-inflammatory; propionic acid class |
| Nicardipine | 33 | Dihydropyridine CCB; antihypertensive | Diltiazem | 211 | Benzothiazepine CCB; antihypertensive; class IV anti-arrhythmic |
| Ticonazole | 33 | Imidazole antifungal | Quinine | 223 | Alkaloid; anti-malarial; antipyretic |
| Nitrendipine | 34 | Dihydropyridine CCB; antihypertensive | Bumetanide | 225 | Loop diuretic; anti-edema; antihypertensive |
| Dibucaine | 35 | Amide local anesthetic | Verapamil | 266 | Phenylalkylamine CCB; antihypertensive |
| Thioridazine | 37 | Piperidine neuroleptic; schizophrenia | Torasemide | 292 | Pyridine-sulfonylurea; loop diuretic; anti-edema; antihypertensive |
| Amlodipine | 42 | Dihydropyridine CCB; antihypertensive | Darifenacin | 296 | Muscarinic acetylcholine receptor blocker; urinary incontinence |
| Cilnidipine | 45 | Dihydropyridine CCB; antihypertensive | Trichlormethiazide | 377 | Thiazide diuretic; anti-edema; antihypertensive |
| Felodipine | 50 | Dihydropyridine CCB; antihypertensive | Probenecid | 385 | Uricosuric; gout and hyperuricemia |
(1)
CCB, Calcium Channel Blocker; Results from (Zheng et al. 2009).