Figure 2.
A: Representative in situ hybridization images of quantified brain areas. Zif268 levels in adult medial prefrontal cortex, striatum, nucleus accumbens, and hippocampus (Top) were compared with juveniles (bottom). Juveniles that formed a place preference at the 10 mg/kg dose had significantly higher Zif268 levels in the dorsal and ventral prefrontal cortex than adults (B). Additionally, there was an age effect where juveniles had significantly higher Zif268 mRNA levels in the striatum (C) and nucleus accumbens (D). There were no significant differences in the CA1 (E), CA3 (F), or DG (G). *p < 0.05