Table 2.

Oxidative stress in antioxidant mutant mouse models

Antioxidant	Model	Oxidative Stress	Oxidative Damage	Ref
Superoxide dismutases
CuZnSod	Sod1−/−	Sensitive	Increased (L, N, P)	[43,44,45,46]
	Sod1 TG	Resistant	Reduced (L)	[47,48,49]
MnSod	Sod2+/−	Sensitive	Increased (N, P)	[23,40,52,138,140, 141]
	Sod2 TG	Resistant	Reduced (L, P)	[142,143,144]
ECSod	Sod3−/−	Sensitive	Increased (L)	[145,146,147,148]
	Sod3 TG	Resistant	Reduced (L)	[149,150]
Catalase
	Cat−/−	No change/sensitive	Increased (L)	[151,152]
	Cat TG	Resistant	Reduced (N)	[47,48,49]
	MCAT (mito)	Resistant	Reduced (N)	[153,154]
Glutathione peroxidases
GPx1	Gpx1−/−	Sensitive	No change/increased (L)	[141,155,156,157, 158,159,160]
	GPx1 TG	Resistant	Reduced (L)	[161]
GPx4	Gpx4+/−	Sensitive	No change/increased (L, N)	[51,162,163]
	GPx4 TG	Resistant	Reduced (L)	[164,165]
Thioredoxins
Trx1	Trx1 TG	Resistant	Reduced (L)	[166,167,168]
Trx2	Txn2+/−	Sensitive	Increased (L, N, P)	[50]
Methionine sulfoxide reductases
MsrA	MsrA−/−	Sensitive	Increased (P)	[121,169,170]
	MsrA TG*	No change	No change (P)	[171]
MsrB	MsrB1−/−	ND	Increased (L, P)	[172]
Peroxiredoxins
Prdx1	Prdx1−/−	Sensitive	Increased (N, P)	[173]
Prdx2	Prdx2−/−	Sensitive	No change/increased (L, P)	[174,175]
Prdx3	Prdx3−/−	Sensitive	Increased (L)	[176,177]
	Prdx3 TG	Resistant	Reduced (L)	[125]
Prdx4	Prdx4−/−	ND	Increased (L)	[178]
	Prdx4 TG	ND	Reduced (N)	[124]
Prdx6	Prdx6−/−	Sensitive	Increased (L, P)	[179,180,181]
	Prdx6 TG	Resistant	Reduced (L, P)	[182,183]

ND = not determined

L = lipid oxidation

N = nucleic acid oxidation

P = protein oxidation

^*= only MEF from animals tested