Table 3.

Glucose homeostasis in antioxidant mutant mouse models

Model	Body weight	Adiposity	Blood glucose or insulin levels	Glucose tolerance or insulin sensitivity	Refs
Knockouts
Sod1−/−	↓	ND	Glucose ↑, Insulin ↓	Improved	[120]
Sod2+/−	–	ND	Glucose –, Insulin ND	Reduced*	[119]
Gpx1−/−	–	ND	Glucose –/↓, Insulin ↓	Improved/–	[80,120]
MsrA−/−	–	ND	Glucose –, Insulin ND	ND	[121]
Transgenics
Sod2 TG	–	–	Glucose –, Insulin –	–	[119]
MCAT (mito)	–	–	Glucose –, Insulin –	–**	[122]
GPx1 TG	↑	↑	Glucose ↑, Insulin ↑	Reduced	[123]
Prdx3 TG	–	ND	Glucose ↓, Insulin –	Improved	[125]
Prdx4 TG	ND	ND	Glucose –, Insulin ND	–	[124]

↓ = values compared to control mice are lower

– = values compared to control mice are unchanged

↑ = values compared to control mice are higher

ND = not determined

^*values from older mice

^**MCAT mice do show improved insulin sensitivity when older mice are tested