Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Alkaline phosphatase (AP) efficiently catalyzes phosphate monoester hydrolysis (top) and nucleotide pyrophosphatase/phosphodiesterase (NPP) efficiently catalyzes phosphate diester hydrolysis (bottom). The position of the leaving group is indicated by LG, and the second substituent of phosphodiesters is indicated by R. (B) and (C) Expected active site interactions in the transition state for phosphoryl transfer in AP and NPP, respectively.
