Table 2.
Summary of the effects of M1 lesion on the ipsilesional hand manual performance
| Mk-CE | Mk-JU | Mk-GE | Mk-RO | Mk-AV | Mk- BI | Mk-VA | Mk-SL | Mk-MO | Mk-JA | Mk-JO | Mk-LAa | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Retrieval score | N | N | N | N | N | Y | Y | N | Y | Y | N | Y |
| Contact time | N | N | Y | Y | N | N | N | Y | N | N | N | Y |
| Total time | – | – | N | N | N | N | Y | Y | Y | N | N | – |
| No. of inj. close to proximal sitesb | 5 | 9 | 3 | 6 | – | 9 | 2 | 3 | 10 | 12 | – | – |
| Average distance to proximal sites (mm)c | 1.5 | 2.6 | 1.3 | 1.4 | – | 1.1 | 1.3 | 1.4 | 1.8 | 0.5 | – | – |
Effect of unilateral lesion of M1 hand representation on the manual performance with the ipsilesional hand as assessed with three parameters: retrieval score in the Modified Brinkman Board task, the contact time in the Modified Brinkman Board task and the total time in the Brinkman box task. Y (“YES”) means that the lesion had an effect, whereas N (“NO”) is for an absence of effect, as observed for each monkey. Note that the parameter total time was not measured in the two monkeys, Mk-CE and Mk-JU, as the Brinkman box task was not introduced yet when these monkeys were under study. The Brinkman box task was not tested in the reversible inactivation sessions with muscimol in Mk-LA. In all monkeys, except Mk-LA, the lesion was permanent (infusion of ibotenic acid)
aIn Mk-LA, a transient lesion was produced by infusion of muscimol in two separate sessions (see Fig. 5)
bThe row gives for each monkey the number of sites where ibotenic acid was infused that were close (≤2 mm) to one or several ICMS sites eliciting proximal muscles activation (shoulder or elbow), as illustrated in Fig. 6 for the monkeys Mk-BI and Mk-SL. These data are plotted in Fig. 7a. As the ICMS maps were incomplete in Mk-AV and Mk-JO, this parameter could not be determined
cFor each site where ibotenic acid was infused and located close (≤2 mm) to a proximal ICMS site (elbow or shoulder), the actual distance between the infusion site and the close proximal ICMS sites were measured and averaged (expressed in mm). These data are plotted in Fig. 7b. As the ICMS maps were incomplete in Mk-AV and Mk-JO, this parameter could not be determined