Figure 1.

GWAS results and plots in the region around APOM. (A) Manhattan plot displaying the -log₁₀ (P-value) of SNPs in the GWAS for 100 Korean RA cases and 600 controls. APOM region is marked. (B) The -log₁₀ (P-value) of SNPs around APOM region. SNPs are represented with diamond dots and the most strongly associated SNP (rs805297) was marked with the largest diamond. The strength of LD relationship (r²) between rs805297 and other SNPs is presented with red color intensities based on the JPT + CHB Hapmap data. The background recombination rate curve is drawn with the JPT + CHB Hapmap data (light blue curve). The location and orientation of APOM and neighboring genes are illustrated under the -log₁₀ plot. (C) LD map of the APOM region. The r² based LD map is drawn with the genotype data of the RA cases and controls using Golden helix SVS software version 7.3.0.