Table 3.
SAM analysis was conducted on microarray data
| Gene ID | Symbol | Gene description | Fold change | q (%) |
|---|---|---|---|---|
| 228729 at | CCNB1 | Cyclin B1 | 9.91 | 3.85 |
| 228069 at | FAM54A | Family with sequence similarity 54, member A | 9.30 | 3.85 |
| 203362 s at | MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 5.44 | 0.00 |
| 209408 at | KIF2C | Kinesin family member 2C | 5.03 | 3.85 |
| 218009 s at | PRC1 | Protein regulator of cytokinesis 1 | 4.99 | 0.00 |
| 218875 s at | FBXO5 | F-box protein 5 | 4.95 | 3.85 |
| 219148 at | PBK | PDZ-binding kinase | 4.85 | 0.00 |
| 219918 s at | ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 4.44 | 3.85 |
| 203213 at | CDK1 | Cyclin-dependent kinase 1 | 4.13 | 3.85 |
| 214710 s at | CCNB1 | Cyclin B1 | 3.88 | 0.00 |
| 208808 s at | HMGB2 | High-mobility group box 2 | 3.81 | 0.00 |
| 208079 s at | AURKA | Aurora kinase A | 3.55 | 0.00 |
NOTE: SAM identifies 12 genes that are statistically upregulated in both tumor and TAHN-1 cells with the highest hTERT promoter activity. Telomerase high data sets from both tumor and TAHN-1 were compared with telomerase low data sets from tumor and TAHN-1 in a paired analysis. The arrays were median centered, a minimum fold change of 3 was set, and a delta value of 6.23 was set to establish a false discovery rate of 3.85% (q value). Using these values, 12 genes were identified that were statistically significantly overexpressed in the cells with high telomerase promoter activity in both tumor and TAHN-1 cells. No genes were found to be significantly underexpressed in these cells.