Table 1.
Body weight, blood glucose concentration, and serum chemistry in experimental mice (duration of diabetes is 3 wk)
| Control | DM | DM + TOP | |
|---|---|---|---|
| Body weight (g) | 39.0 ± 3.3 | 31.6 ± 2.2b | 29.4 ± 3.3b |
| Blood glucose (mg/dl) | 165 ± 53.3 | >250a | >250a |
| Na (mmol/liter) | 149 ± 2.1 | 142 ± 4.1a | 143 ± 4.4a |
| K (mmol/liter) | 8.1 ± 0.9 | 6.1 ± 2.6a | 7.1 ± 1.1 |
| Cl (mmol/liter) | 121 ± 2.3 | 111 ± 3.0a | 112 ± 4.4a |
| Ca+2 (mmol/liter) | 1.24 ± 0.1 | 1.23 ± 0.1 | 1.26 ± 0.1 |
| TCO2 (mmol/liter) | 15 ± 2.6 | 18 ± 3.4 | 16 ± 5.0 |
| BUN (mg/dl) | 21 ± 2.8 | 22 ± 7.6 | 24 ± 4.5 |
| Creatinine (mg/dl) | 0.21 ± 0.03 | 0.20 ± 0.00 | 0.20 ± 0.00 |
| Hematocrit (% PCV) | 43 ± 3.0 | 46 ± 3.3 | 46 ± 2.2 |
| Hemoglobin (g/dl) | 14.7 ± 1.0 | 15.7 ± 1.1 | 15.5 ± 0.8 |
| AnGap (mmol/liter) | 20.6 ± 2.5 | 19.3 ± 4.4 | 22.9 ± 4.5 |
Values are mean ± sem, n = 10.
a
P < 0.05 for difference from controls.
b
P < 0.0001 for difference from controls. PCV, Packed cell volume; AnGap, anion gap.