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. 2011 Nov 22;153(1):17–28. doi: 10.1210/en.2011-1439

Fig. 1.

Fig. 1.

Effect of ZA therapy on bone mass, μCT measurements. A, Representative three-dimensional reconstructions of the metaphyseal trabecular bone of the distal femurs. B–E, The femurs from ZA-treated mice had significantly higher trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), and significantly lower trabecular separation (Tb.Sp) compared with VC-treated mice. F, Tissue mineral density (TMD) was similar between the VC and ZA groups. G, Cross-sectional images of the diaphyseal cortical bone. Numerous cavities devoid of mineral were noted near the endosteum in the ZA group. H, No difference was found in the total cross-sectional area inside the periosteal envelop (Tt.Ar) between groups. I–K, The femurs in the ZA group had significantly higher cortical bone area (Ct.Ar), cortical area fraction (Ct.Ar/Tt.Ar), and cortical thickness (Ct.Th) than the VC group. L, Endosteal perimeters were significantly smaller in the ZA than VC group. M, The cortical bone in the ZA group had significantly less cortical porosity (Ct.Po) than the VC group. n = 7/group; *, P < 0.05; **, P < 0.01; ***, P < 0.001.