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Effects of goldenseal and silymarin on serum APAP concentration in APAP-induced liver failure. Rats were administered goldenseal or silymarin 2, 18, and 26 h before and 6 h after oral APAP (400 mg/kg) administration. Blood was collected 8 h after APAP administration and serum APAP concentrations were determined. Values represent the mean ± SEM of five rats
