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Characterization of in vitro formation and depletion of 5OH-omeprazole and omeprazole sulfone in pooled HLM. Formation (A) and depletion (B) of 5OH-omeprazole. Formation (C) and depletion (D) of omeprazole sulfone. B, the percentage remaining of 5OH-omeprazole over time is provided with (■) and without (●) NADPH. Error bars represent the S.D. of three measurements.
