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Clearance of GHB in rats administered GHB with and without l-lactate. GHB was administered intravenously at 1500 mg/kg followed by l-lactate as a 66 mg/kg bolus and 302.5 mg/kg per hour infusion. Data are presented as mean ± S.D. (n = 4–5/group). Clearances between groups administered GHB alone and with l-lactate were compared using Student's t tests or Mann-Whitney rank sum tests. *, P < 0.05.
