TABLE 1.

B/P partitioning in rats administered GHB (±) l-lactate

Using a Student's t test, no significant difference was determined between animals administered GHB at 1500 mg/kg compared to those administered GHB at 1500 mg/kg + l-lactate (P > 0.05). Data presented as mean (S.D.).

Regimen	B/P Ratio
GHB 400-1500 mg/kg†	0.75
GHB 600 or 1500 mg/kg + l-lactate†	0.76
GHB 1500 mg/kg††	0.74 (0.07)
GHB 1500 mg/kg + l-lactate 66 mg/kg + 302.5 mg/kg per hour††	0.75 (0.07)

^† Ratio determined using data from all animals, including serial and sacrificial sampling studies (n = 74 rats total) and both l-lactate doses (330 mg/kg + 121 mg/kg per hour and 66 mg/kg + 302.5 mg/kg per hour). No S.D. was determined because sacrificial sampling did not allow determination of individual B/P ratios across a concentration range.

^†† Mean of individual B/P ratios determined from serial sampling study only (n = 4–5 in each group). These values were used for statistical comparison.