TABLE 1.
Physiological function and diseases correlation of TMEM16 family members
| Family Members | Function and Diseases Correlation | References |
|---|---|---|
| TMEM16A | Tracheomalacia; gastrointestinal motility; pain sensation; GIST; salivary gland secretion; airway epithelial secretion. | Rock et al., 2008, 2009; Huang et al., 2009; Hwang et al., 2009; Romanenko et al., 2010; Hwang et al., 2011; Mazzone et al., 2011 |
| TMEM16B | Photoreceptor signal in retina; olfaction signal transduction in sensory neurons. | Stephan et al., 2009; Stöhr et al., 2009; Rasche et al., 2010; Billig et al., 2011 |
| TMEM16E | Gnathodiaphyseal dysplasia; proximal limb-girdle muscular dystrophy; distal non-dysferlin Miyoshi myopathy. | Kleene and Gesteland, 1991; Tsutsumi et al., 2004; Mizuta et al., 2007 |
| TMEM16F | Ca2+-dependent phospholipid scramblases for PtdSer exposure in platelets; mutations found in Scott syndrome. | Suzuki et al., 2010; Castoldi et al., 2011 |
| TMEM16G | Expression in prostate cancer and normal prostate. | Bera et al., 2004; Das et al., 2007 |
| TMEM16K | Mutation found in autosomal-recessive cerebellar ataxia. | Vermeer et al., 2010 |