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. 2012 Jan;81(1):86–96. doi: 10.1124/mol.111.074393

Fig. 5.

Fig. 5.

Expression of the CYP3A4 mRNA transcripts determined by RNA sequencing (A) (n = 1) and RT-qPCR (B) (n = 3) in primary human hepatocytes after drug treatments. The primary human hepatocytes were treated with DMSO solvent control (0.1%), RIF (10 μM), or PB (750 μM) for 24 h. Three primary human hepatocytes were isolated from male donors at age of 55, 56, and 58. In the RT-qPCR experiment, the average expression level treated with DMSO is set as 1. Fold changes of expression levels of the transcripts after drug treatment are compared with the values in DMSO. Black column, mean; bar, S.D. of biological triplicate samples.