Fig. 6.

Relative fold changes of the CYP3A4 mRNA transcripts determined by RT-qPCR in liver tissues from humans of various ages. Average expression level in fetal liver is set as 1. Fold changes of expression levels of mRNA transcripts in each sample are compared with the fetal average value. Fetal livers include four samples with estimated gestational ages (EGA) from 170 to 227 days. Neonatal/pediatric livers contain four samples from postnatal ages (PNA) 4 days to 7 years; the age of four adult livers ranges from 17 to 36 years.