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. 2012 Jan;81(1):3–11. doi: 10.1124/mol.111.073643

TABLE 1.

Antagonist and Concentration EROD Activity (Percentage of 10 nM TCDD)
HaCaT HepG2 T84
% % %
CH223191
    1 μM 33 ± 6 58 ± 16 30 ± 8
CHD-5
    1 μM 27 ± 6 58 ± 13 29 ± 8
    10 μM 21 ± 11 28 ± 9 28 ± 9
CHD-7
    1 μM 104 ± 10* 82 ± 9 94 ± 9*
    10 μM 96 ± 4 98 ± 16 68 ± 3
CHD-8
    1 μM 113 ± 4* 68 ± 7 103 + 9*
    10 μM 109 ± 9 79 ± 7 87 ± 2*
CHD-11
    1 μM 36 ± 10 33 ± 10 32 ± 7
    10 μM 23 ± 3 29 ± 9 28 ± 9
CHD-12
    1 μM 29 ± 7 34 + 8 31 ± 8
    10 μM 21 ± 2 29 + 9 24 ± 10
*

Statistically different (P < 0.05) from CH223191.

Statistically different (P < 0.05) from CHD-5, CHD-11, and CHD-12 at the corresponding concentrations.

Statistically different (P < 0.05) from CHD-11 and CHD-12 at the corresponding concentrations.