Fig. 1.

Cross-clade neutralizing activity of macaque plasma. (A) Plasma from 5 SHIV_AD8-infected macaques were tested for neutralizing activity against a cross-clade tier 2 pseudovirus panel, the autologous virus (SHIV_AD8), and a negative control virus (SIVmac239). Values represent the plasma dilution at which 50% neutralization was detected. Scores were designated based on an algorithm incorporating breadth and potency (2). (B) Plasma from macaque CE8J was tested against a larger cross-clade pseudovirus panel containing 21 isolates. Boxes are color coded as follows: gray, IC₅₀ < 1:100; green, 1:100 < IC₅₀ < 1:300; yellow, 1:300 < IC₅₀ < 1:500; orange, 1:500 < IC₅₀ < 1:1,000; red, IC₅₀ > 1:1,000.