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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Neurovirol. 2011 Aug 11;17(5):496–499. doi: 10.1007/s13365-011-0050-5

Fig. 2. Activated microglia/macrophages within the hippocampus and dentate gyrus of chimeric mice.

Fig. 2

One measure of inflammation is the presence of activated microglia/macrophages, detected through RCA-I lectin histochemistry. The numbers of RCA-I+ cells were enumerated for mice sacrificed on day 14 p.i. There were no irradiated IL-6-deficient chimeric mice reconstituted with IL-6-deficient donor cells (IL-6−/−-to-IL-6−/−) with or without seizures or irradiated IL-6-deficient chimeric mice reconstituted with wild-type donor cells (WT-to-IL-6−/−) with seizures for this time point. The irradiated 3-month-old wild-type chimeric mice reconstituted with wild-type donor cells (WT-to-WT) had a significantly higher number of RCA-I+ cells than the irradiated 3-month-old wild-type chimeric mice reconstituted with IL-6-deficient donor cells (IL-6−/−-to-WT). ‡, p < 0.05 (ANOVA, Fisher’s PLSD post hoc test). Results are mean + SEM of groups with one to fifteen mice per group.