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Effect of whole-brain irradiation on mRNA expression of VEGF, Ang-1, Tie-2 and Ang-2 in rat brain. Compared with sham-irradiated controls, radiation significantly downregulated mRNA expression levels of VEGF (panel A), Ang-1 (panel B) and Tie-2 (panel C) in rat brains. In contrast, mRNA expression levels of Ang-2 were upregulated by radiation (panel D). Data shown are means ± SEM for each group (n = 4). *Statistically significant difference from control (P < 0.05).
