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TNFR1 deletion decreases synaptic excitatory transmission and prevents TNF-α-induced increase of synaptic excitatory transmission. A) Representative imagography shows mEPSC recording from primary cortex neurons of WT, TNFR1−/−, and TNFR2−/− mice in the absence and presence of TNF-α application. B) Average mEPSC peak amplitude before and after TNF-α treatment. C) Cumulative probability of the peak amplitude and frequency of mEPSC before and after TNF-α treatment. *P < 0.01.
