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CRALBP and atRA levels are increased during LIRD. A) CRALBP immunohistochemistry in the LIRD retinas, demonstrating increased levels at light damage onset. Scale bar = 20 μm. B–D) atRA concentrations increase during LIRD. Typical HPLC chromatograms of atRA standard (B), control (C), and LIRD retinas (pLX0; D). Peak 1 denotes atRA. E) Quantification analysis showed an increase in atRA levels during LIRD. *P < 0.05 vs. control, n = 9.
