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. 2012 Jan;26(1):81–92. doi: 10.1096/fj.11-192914

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Figure 3. — RA signaling is present in adult retinas and activated during LIRD. A) CRABPII was observed in the INL and GCL of control retinas. B, C) Western blots (C) and data quantification (D) showed that CRABPII levels increased immediately following LIRD, but reduced to almost undetectable levels by pLX7 before oscillating around normal levels from pLX30 to pLX120, n = 9. D–I) RARα (D–F), RARβ (G–I), RXRα (D, G), RXRβ (E, H), RXRγ (F, I), and colocalization of RARs/RXRs were observed in the INL and GCL of control retinas. J–K) Western blots (J) and data quantification (K) showed that RA signaling was activated during LIRD. RARβ, RXRα, and RARγ levels increased, while RARα and RXRβ levels showed no change, n = 9. Scale bars = 20 μm.