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. 2012 Jan;26(1):81–92. doi: 10.1096/fj.11-192914

Figure 7.

Figure 7.

CaMKII signaling is involved in neuritogenesis during LIRD. A, B) Western blots (A) and data quantification (B) showed that LIRD increased βCaMKII protein levels, while αCaMKII protein levels showed no change. Ratio of αCaMKII/βCaMKII proteins decreased, n = 9. C, D) Western blots (C) and data quantification (D) showed that LIRD increased the protein levels of GluA2, but GluA1 levels showed no change, n = 9. E, F) KN-62 (F) accelerated neuritogenesis compared to vehicle (E). Scale bar = 20 μm. G) Summary data (means±se) for the length of rod bipolar cell dendrites. **P < 0.01 vs. pLX21 (vehicle), n = 5. H, I) Western blots (H) and data quantification (I) showed that LIRD had no effect on the protein levels of αCaMKII but increased the protein levels of βCaMKII and RARβ, especially in Rdh12+/− mice. Ratio of αCaMKII to βCaMKII proteins was therefore reduced; n = 3.